Researchers are still working on the big question: how are cannabinoids, with a focus on CBD, is playing on the human system? One thing is sure: CBD is not psychoactive.
Why is CBD Non-Psychoactive?
We will make it simple: CBD is non-psychoactive because it doesn’t work with the psychoactive receptors of the brain.
Let’s explain: The receptors CB1 and CB2 are highly concentrated in the brain, and when THC ( Tetrahydrocannabinol) binds to it, the CB1 receptors are stimulated causing the psychoactive effect. CBD does not have the same binding affinity for the CB1 and CB2 receptors compared to THC.
THC vs CBD: The Friendly Battle
Now you understood CBD doesn’t bind well with CB1 receptors, we can go to the next step:
CBD is an antagonist of CB1 agonists.
This means that it doesn’t act directly (activating or suppressing) CB1 receptors. Instead, it acts to suppress the CB1-activating qualities of a cannabinoid as THC. This process explains why CBD is known to reduce the intoxicating effects of THC, such as memory impairment and paranoia.
Since CBD has no secondary effects; non-psychoactive and non-toxic, it is legal in many countries and has less stigma, than THC, associated with it.